Michael Heidelberger, 1933

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  • Michael Heidelberger
چکیده

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Michael Heidelberger and the demystification of antibodies

Heidelberger and Avery’s early experiments hinged on a simple element: nitrogen. Based on its presence or absence, the duo showed that the antibody-reactive substances on pneumococcal bacterial capsules were nitrogen-free carbohydrates, and that the reacting antibodies were nitrogencontaining proteins (see “How Heidelberger and Avery sweetened immunology” JEM 202:1306). The discovery that antib...

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Michael Heidelberger and the demystification of antibodies

Having defined the protein nature of antibodies under the tutelage of Oswald Avery, Michael Heidelberger was the first to apply mathematics to the reaction of antibodies and their antigens (the "precipitin reaction"). Heidelberger's calculations launched decades of research that helped reveal the specificity, function, and origin of antibodies.

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Heidelberger and the demystification of antibodies

Heidelberger and Avery’s early experiments hinged on a simple element: nitrogen. Based on its presence or absence, the duo showed that the antibody-reactive substances on pneumococcal bacterial capsules were nitrogen-free carbohydrates, and that the reacting antibodies were nitrogencontaining proteins (see “How Heidelberger and Avery sweetened immunology” JEM 202:1306). The discovery that antib...

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تاریخ انتشار 2018